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Background: Racial and ethnic minorities have well-established disparities in cancer prevention, detection, treatment, and survival. A diverse oncology workforce improves the gap in cancer care for vulnerable populations. However, physicians, researchers, and others who are Underrepresented in Medicine (UIM) face unique challenges in obtaining mentorship and sponsorship, and there is a lack of safe spaces for them to thrive, forcing many to leave medicine entirely. To further efforts in improving the care of vulnerable populations and to create a welcoming environment for UIM medical trainees, the Florez Lab (formerly known as the Duma Lab) was founded by Dr. Narjust Florez in 2019 at the University of Wisconsin. Subsequently, Dr. Florez moved to Dana-Farber Cancer Institute and expanded the lab's reach. Here, we describe the history and legacy of our innovative group. Method(s): The Florez Lab is composed of 39 members, mostly UIM from different backgrounds and locations;members range from college students to faculty. It began as an allfemale team but now includes #HeforShe member allies. Several members joined as trainees, but are now junior faculty at NCI designated cancer centers and pay it forward by mentoring the next generation of the Florez Lab. We focus on social justice issues in medicine, including discrimination and gender bias in academic and clinical medicine, global oncology, and cancer health disparities, with a focus on thoracic oncology. Result(s): To date, the Florez Lab has secured research funding from several institutions and organizations, and has published 15 original articles, 11 editorials, 4 review articles, and 2 book chapters in addition to over 20 poster presentations at national and international conferences. Members have presented research findings at a wide array of national and international conferences, including the American Society of Clinical Oncology (ASCO) Annual Meeting and the World Conference on Lung Cancer, and the American Association for Cancer Research (AACR) Annual Meeting. The lab collaborates with multiple organizations, including the COVID-19 and Cancer Consortium (CCC19), ASCO Health Equity Committee, and the Lancet Commission: Women & Cancer. The lab is far-reaching;the #DumaLab and #FlorezLab hashtag is used on Twitter to amplify published work and advocacy efforts in improving the diversity of the oncology workforce and clinical trial enrollment. In 2021 the Florez Lab began a collaboration with Medscape and is the first lab to have a dedicated column, where we discuss issues related to social justice in medicine and cancer health disparities;the column has reached over 60,000 readers in less than one year. Conclusion(s): The success of the Florez Lab illustrates the importance of providing opportunities for, supporting, and amplifying the success of UIM trainees. Results indicate that the collaboration of UIM trainees is productive, meaningful, and necessary. Efforts should be made to continue supporting UIM trainees from all backgrounds and levels.
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This paper presents the results of the engineering student's perception of the implementation of virtual laboratories and simulators in the online modality during the COVID-19 pandemic. It was done through a questionnaire that was designed and validated to later apply it online and collect the student's perception regarding their previous experience, learning, self-learning, teaching practice, emotions and the curriculum around virtual laboratories and simulators. It is concluded that they are tools accepted by the students and that they facilitate learning and contribute to achieve the competencies required in engineering, even when the education is in the distance modality. © 2022 IEEE.
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Dermatological manifestations are a frequent sign in the course of covid-19, Gianotti-Crosti syndrome has being observed as a manifestation after sars-cov-2 infection, and should be considered as a possible differential diagnosis. We present the case of an 11-month-old male, who goes to the emergency room with fever of 39.9 °C, is diagnosed as pharyngitis and is discharged home;two weeks later, he went to reassessment due to a maculopapular rash predominantly on the trunk, extremities, anterior and posterior chest, respecting the soles and palms, it was classified as a febrile exanthematous disease. In the context of a covid-19 pandemic, a rapid antigen test was taken with a non-reactive result and serologies for sars-cov-2 igg positive.
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Objectives: Aicardi-Goutières syndrome (AGS) is a rare neurological disease with cutaneous manifestations. We report a case of AGS with chilblain-like lesions and psychiatric symptoms, which are exceptionally presented in these patients. Moreover, the diagnostic process was challenging since skin lesions appeared during the COVID-19 pandemic, when chilblain-like lesions where commonly seen among pediatric and adolescent populations. Method: A 17-year-old man with personal history of pychomotor delay and limb spasticity, was seen at the emergency department with acral lesions worsened by exposure to cold, suggestive of perniosis. He presented one year later, during the first wave of the COVID-19 pandemic in Spain, with new chilblain-like lesions on his feet. Histological findings were consistent with trombotic vasculophaty. Coagulation workup and inmunological investigations were normal. Ten months later, the patient presented at the emergency department with hallucinations and catatonia, requiring hospitalization. Computed tomographic scan was performed showing intracranial calcifications. Results: Based on the developmental delay, spasticity, psychomotor retardation, cutaneous and radiological findings, AGS was suspected and confirmed with a genetic testing (biallelic pathogenic variants in SAMHD1). Discussion: AGS is considered a type I interferonopathie presenting with an early onset encephalopathy;however it has a broad clinical spectrum, with milder phenotypes of later onset, where the presenting symptom may be cutaneous rather than neurological. The genetic basis of AGS have highlighted the fundamental role of nucleic acid signalling in the induction of type I IFN and the range of phenotypes associated with mutations in these genes is much broader than previously realized. Skin manifestations represent the most prominent extraneurologic features, being chilblain-like lesions the most frequent. However, to our knowledge, there is only one previous report of AGS with psychiatric symptoms. The dermatologist must be aware of this syndrome, and consider it when assessing patients with chilblain-like lesions in the presence of neurological symptoms, even if they are mild.
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BACKGROUND: SARS-CoV-2, the COVID-19 causative agent, has infected millions of people and killed over 1.6 million worldwide. A small percentage of cases persist with prolonged positive RT-PCR on nasopharyngeal swabs. The aim of this study was to determine risk factors for prolonged viral shedding amongst patient's basal clinical conditions. METHODS: We have evaluated all 513 patients attended in our hospital between 1 March and 1 July. We have selected all 18 patients with prolonged viral shedding and compared them with 36 sex-matched randomly selected controls. Demographic, treatment and clinical data were systematically collected. RESULTS: Global median duration of viral clearance was 25.5 days (n = 54; IQR, 22-39.3 days), 48.5 days in cases (IQR 38.7-54.9 days) and 23 days in controls (IQR 20.2-25.7), respectively. There were not observed differences in demographic, symptoms or treatment data between groups. Chronic rhinosinusitis and atopy were more common in patients with prolonged viral shedding (67%) compared with controls (11% and 25% respectively) (P < 0.001 and P = 0.003). The use of inhaled corticosteroids was also more frequent in case group (P = 0.007). Multivariate analysis indicated that CRS (odds ratio [OR], 18.78; 95% confidence interval [95%CI], 3.89-90.59; P < 0.001) was independently associated with prolonged SARS-CoV-2 RNA shedding in URT samples, after adjusting for initial PCR Ct values. CONCLUSION: We found that chronic rhinosinusitis and atopy might be associated with increased risk of prolonged viral shedding. If confirmed in prospective trials, this finding might have clinical implications for quarantine duration due to increased risk of pandemic spread.